diff --git a/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts b/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
index 8f4828073d0..bee794dec86 100644
--- a/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
+++ b/public/app/plugins/datasource/tempo/SearchTraceQLEditor/utils.ts
@@ -5,7 +5,7 @@ import { getTemplateSrv } from '@grafana/runtime';
 import { VariableFormatID } from '@grafana/schema';
 
 import { TraceqlFilter, TraceqlSearchScope } from '../dataquery.gen';
-import { getEscapedSpanNames } from '../datasource';
+import { getEscapedRegexValues, getEscapedValues } from '../datasource';
 import TempoLanguageProvider from '../language_provider';
 import { intrinsics } from '../traceql/traceql';
 import { Scope } from '../types';
@@ -32,11 +32,16 @@ export const interpolateFilters = (filters: TraceqlFilter[], scopedVars?: Scoped
 
 const isRegExpOperator = (operator: string) => operator === '=~' || operator === '!~';
 
-const escapeValues = (values: string[]) => getEscapedSpanNames(values);
-
 export const valueHelper = (f: TraceqlFilter) => {
-  const value =
-    Array.isArray(f.value) && isRegExpOperator(f.operator!) && !f.isCustomValue ? escapeValues(f.value) : f.value;
+  let value = f.value;
+
+  if (Array.isArray(value) && !f.isCustomValue) {
+    value = getEscapedValues(value);
+
+    if (isRegExpOperator(f.operator!)) {
+      value = getEscapedRegexValues(value);
+    }
+  }
 
   if (Array.isArray(value) && value.length > 1) {
     return `"${value.join('|')}"`;
diff --git a/public/app/plugins/datasource/tempo/datasource.test.ts b/public/app/plugins/datasource/tempo/datasource.test.ts
index 532e5835153..f66520555f5 100644
--- a/public/app/plugins/datasource/tempo/datasource.test.ts
+++ b/public/app/plugins/datasource/tempo/datasource.test.ts
@@ -41,7 +41,8 @@ import {
   makeServiceGraphViewRequest,
   makeTempoLink,
   getFieldConfig,
-  getEscapedSpanNames,
+  getEscapedRegexValues,
+  getEscapedValues,
   makeHistogramLink,
   makePromServiceMapRequest,
 } from './datasource';
@@ -778,12 +779,12 @@ describe('Tempo service graph view', () => {
       'server.cluster.local:9090^/sample.test(.*)?',
       'test\\path',
     ];
-    let escaped = getEscapedSpanNames(spanNames);
+    let escaped = getEscapedRegexValues(getEscapedValues(spanNames));
     expect(escaped).toEqual([
       '/actuator/health/\\\\*\\\\*',
       '\\\\$type \\\\+ \\\\[test\\\\]\\\\|HTTP POST - post',
       'server\\\\.cluster\\\\.local:9090\\\\^/sample\\\\.test\\\\(\\\\.\\\\*\\\\)\\\\?',
-      'test\\\\\\\\path',
+      'test\\\\path',
     ]);
   });
 
diff --git a/public/app/plugins/datasource/tempo/datasource.ts b/public/app/plugins/datasource/tempo/datasource.ts
index 968b59cd26b..6338cf58b98 100644
--- a/public/app/plugins/datasource/tempo/datasource.ts
+++ b/public/app/plugins/datasource/tempo/datasource.ts
@@ -1081,7 +1081,7 @@ function errorAndDurationQuery(
       }
     });
   }
-  const spanNames = getEscapedSpanNames(labels);
+  const spanNames = getEscapedRegexValues(getEscapedValues(labels));
 
   if (spanNames.length > 0) {
     errorRateBySpanName = buildExpr(errorRateMetric, 'span_name=~"' + spanNames.join('|') + '"', request);
@@ -1151,8 +1151,12 @@ function makePromLink(title: string, expr: string, datasourceUid: string, instan
 
 // TODO: this is basically the same as prometheus/datasource.ts#prometheusSpecialRegexEscape which is used to escape
 //  template variable values. It would be best to move it to some common place.
-export function getEscapedSpanNames(values: string[]) {
-  return values.map((value: string) => value.replace(/\\/g, '\\\\\\\\').replace(/[$^*{}\[\]\'+?.()|]/g, '\\\\$&'));
+export function getEscapedRegexValues(values: string[]) {
+  return values.map((value: string) => value.replace(/[$^*{}\[\]\'+?.()|]/g, '\\\\$&'));
+}
+
+export function getEscapedValues(values: string[]) {
+  return values.map((value: string) => value.replace(/["\\]/g, '\\$&'));
 }
 
 export function getFieldConfig(
diff --git a/public/app/plugins/datasource/tempo/language_provider.test.ts b/public/app/plugins/datasource/tempo/language_provider.test.ts
index 4a8a8bb1b83..fb0c883a4ee 100644
--- a/public/app/plugins/datasource/tempo/language_provider.test.ts
+++ b/public/app/plugins/datasource/tempo/language_provider.test.ts
@@ -174,7 +174,7 @@ describe('Language_provider', () => {
             },
           ],
         })
-      ).toBe(`{name${operator}"api/v2/variants/by-upc/\\\\(\\\\?P<upc>\\\\[\\\\\\\\s\\\\\\\\S\\\\]\\\\*\\\\)/\\\\$"}`);
+      ).toBe(`{name${operator}"api/v2/variants/by-upc/\\\\(\\\\?P<upc>\\\\[\\\\s\\\\S\\\\]\\\\*\\\\)/\\\\$"}`);
     });
     it('two fields with everything filled in', () => {
       expect(