diff --git a/e2e/custom-plugins/frontend-sandbox-panel-test/module.js b/e2e/custom-plugins/frontend-sandbox-panel-test/module.js
deleted file mode 100644
index dafd0aceb31..00000000000
--- a/e2e/custom-plugins/frontend-sandbox-panel-test/module.js
+++ /dev/null
@@ -1,41 +0,0 @@
-define(['react', '@grafana/data'], function (React, grafanaData) {
-  const HelloWorld = () => {
-    const createIframe = () => {
-      // direct iframe creation
-      const iframe = document.createElement('iframe');
-      iframe.src = 'about:blank';
-      iframe.id = 'createElementIframe';
-      iframe.style.width = '10%';
-      iframe.style.height = '10%';
-      iframe.style.border = 'none';
-      document.body.appendChild(iframe);
-
-      // via innerHTML
-      const div = document.createElement('div');
-      document.body.appendChild(div);
-      div.innerHTML =
-        '<iframe src="about:blank" id="innerHTMLIframe" style="width: 10%; height: 10%; border: none;"></iframe>';
-
-      const adjacentIframe = `<iframe src="about:blank" id="adjacentIframe" width="10%" height="10%" frameBorder="0"></iframe>`;
-      document.querySelector('body').insertAdjacentHTML('beforeend', adjacentIframe);
-    };
-    const handleClick2 = () => {
-      console.log('hello world 2');
-    };
-    const handleClick3 = () => {
-      console.log('hello world 3');
-    };
-
-    return React.createElement(
-      'div',
-      { className: 'frontend-sandbox-test' },
-      React.createElement('button', { onClick: createIframe, 'data-testid': 'panel-button-1' }, 'Craete iframes'),
-      React.createElement('button', { onClick: handleClick2, 'data-testid': 'panel-button-2' }, 'Button 2'),
-      React.createElement('button', { onClick: handleClick3, 'data-testid': 'panel-button-3' }, 'Button 3')
-    );
-  };
-
-  const plugin = new grafanaData.PanelPlugin(HelloWorld);
-
-  return { plugin };
-});
diff --git a/e2e/custom-plugins/frontend-sandbox-panel-test/plugin.json b/e2e/custom-plugins/frontend-sandbox-panel-test/plugin.json
deleted file mode 100644
index a77283a0a6b..00000000000
--- a/e2e/custom-plugins/frontend-sandbox-panel-test/plugin.json
+++ /dev/null
@@ -1,25 +0,0 @@
-{
-  "$schema": "https://raw.githubusercontent.com/grafana/grafana/master/docs/sources/developers/plugins/plugin.schema.json",
-  "type": "panel",
-  "name": "Sandbox test plugin",
-  "id": "sandbox-test-panel",
-  "info": {
-    "keywords": ["panel"],
-    "description": "",
-    "author": {
-      "name": "Grafana"
-    },
-    "logos": {
-      "small": "img/logo.svg",
-      "large": "img/logo.svg"
-    },
-    "links": [],
-    "screenshots": [],
-    "version": "1.0.0",
-    "updated": "2023-06-27"
-  },
-  "dependencies": {
-    "grafanaDependency": ">=10.0",
-    "plugins": []
-  }
-}
diff --git a/e2e/plugins-sandbox-suite/panelSandbox.spec.ts b/e2e/plugins-sandbox-suite/panelSandbox.spec.ts
deleted file mode 100644
index ab75b59711f..00000000000
--- a/e2e/plugins-sandbox-suite/panelSandbox.spec.ts
+++ /dev/null
@@ -1,27 +0,0 @@
-import { e2e } from '@grafana/e2e';
-
-import panelSandboxDashboard from './panelSandboxDashboard.json';
-
-const DASHBOARD_ID = 'c46b2460-16b7-42a5-82d1-b07fbf431950';
-
-describe('Panel sandbox', () => {
-  beforeEach(() => e2e.flows.login(e2e.env('USERNAME'), e2e.env('PASSWORD'), true));
-
-  describe('Sandbox disabled', () => {
-    const queryParams = { '__feature.pluginsFrontendSandbox': false };
-
-    it('Add iframe to body', () => {
-      e2e.flows.importDashboard(panelSandboxDashboard, 1000, true);
-      e2e.flows.openDashboard({ uid: DASHBOARD_ID, queryParams });
-
-      cy.get('[data-testid="panel-button-1"]').click();
-
-      cy.get('#createElementIframe').should('exist');
-      cy.get('#innerHTMLIframe').should('exist');
-      cy.get('#adjacentIframe').should('exist');
-    });
-  });
-
-  afterEach(() => e2e.flows.revertAllChanges());
-  after(() => e2e().clearCookies());
-});
diff --git a/e2e/plugins-sandbox-suite/panelSandboxDashboard.json b/e2e/plugins-sandbox-suite/panelSandboxDashboard.json
deleted file mode 100644
index 0ea1ca81d24..00000000000
--- a/e2e/plugins-sandbox-suite/panelSandboxDashboard.json
+++ /dev/null
@@ -1,58 +0,0 @@
-{
-  "annotations": {
-    "list": [
-      {
-        "builtIn": 1,
-        "datasource": {
-          "type": "grafana",
-          "uid": "-- Grafana --"
-        },
-        "enable": true,
-        "hide": true,
-        "iconColor": "rgba(0, 211, 255, 1)",
-        "name": "Annotations & Alerts",
-        "type": "dashboard"
-      }
-    ]
-  },
-  "editable": true,
-  "fiscalYearStartMonth": 0,
-  "graphTooltip": 0,
-  "id": 118,
-  "links": [],
-  "liveNow": false,
-  "panels": [
-    {
-      "datasource": {
-        "type": "testdata",
-        "uid": "PD8C576611E62080A"
-      },
-      "gridPos": {
-        "h": 8,
-        "w": 12,
-        "x": 0,
-        "y": 0
-      },
-      "id": 1,
-      "title": "Sandbox Panel test",
-      "type": "sandbox-test-panel"
-    }
-  ],
-  "refresh": "",
-  "schemaVersion": 38,
-  "style": "dark",
-  "tags": [],
-  "templating": {
-    "list": []
-  },
-  "time": {
-    "from": "now-6h",
-    "to": "now"
-  },
-  "timepicker": {},
-  "timezone": "",
-  "title": "Sandbox Panel Test",
-  "uid": "c46b2460-16b7-42a5-82d1-b07fbf431950",
-  "version": 1,
-  "weekStart": ""
-}
diff --git a/e2e/start-and-run-suite b/e2e/start-and-run-suite
index 3351a19fdc4..d29b7775b96 100755
--- a/e2e/start-and-run-suite
+++ b/e2e/start-and-run-suite
@@ -16,7 +16,7 @@ if [ "$BASE_URL" != "" ]; then
     echo -e "BASE_URL set, skipping starting server"
 else
   # Start it in the background
-  GF_PATHS_PLUGINS=../../../e2e/custom-plugins/ ./scripts/grafana-server/start-server $LICENSE_PATH 2>&1 > scripts/grafana-server/server.log &
+  ./scripts/grafana-server/start-server $LICENSE_PATH 2>&1 > scripts/grafana-server/server.log &
   ./scripts/grafana-server/wait-for-grafana
 fi
 
diff --git a/packages/grafana-runtime/src/config.ts b/packages/grafana-runtime/src/config.ts
index 94da6d52272..2ef92f24027 100644
--- a/packages/grafana-runtime/src/config.ts
+++ b/packages/grafana-runtime/src/config.ts
@@ -194,9 +194,7 @@ export class GrafanaBootConfig implements GrafanaConfig {
       systemDateFormats.update(this.dateFormats);
     }
 
-    if (this.buildInfo.env === 'development') {
-      overrideFeatureTogglesFromUrl(this);
-    }
+    overrideFeatureTogglesFromUrl(this);
 
     if (this.featureToggles.disableAngular) {
       this.angularSupportEnabled = false;