diff --git a/docs/sources/developers/plugins/plugin.schema.json b/docs/sources/developers/plugins/plugin.schema.json
index 1913d9aef08..3442ae7d2a4 100644
--- a/docs/sources/developers/plugins/plugin.schema.json
+++ b/docs/sources/developers/plugins/plugin.schema.json
@@ -308,6 +308,10 @@
       "type": "boolean",
       "description": "For data source plugins, if the plugin supports metric queries. Used to enable the plugin in the panel editor."
     },
+    "multiValueFilterOperators": {
+      "type": "boolean",
+      "description": "For data source plugins, if the plugin supports multi value operators in adhoc filters."
+    },
     "pascalName": {
       "type": "string",
       "description": "[internal only] The PascalCase name for the plugin. Used for creating machine-friendly identifiers, typically in code generation. If not provided, defaults to name, but title-cased and sanitized (only alphabetical characters allowed).",
diff --git a/package.json b/package.json
index 91c01aca4f8..6a50860c13c 100644
--- a/package.json
+++ b/package.json
@@ -268,7 +268,7 @@
     "@grafana/prometheus": "workspace:*",
     "@grafana/runtime": "workspace:*",
     "@grafana/saga-icons": "workspace:*",
-    "@grafana/scenes": "^5.10.1",
+    "@grafana/scenes": "^5.11.0",
     "@grafana/schema": "workspace:*",
     "@grafana/sql": "workspace:*",
     "@grafana/ui": "workspace:*",
diff --git a/packages/grafana-data/src/types/datasource.ts b/packages/grafana-data/src/types/datasource.ts
index 8609dcff2a1..4d5b332350e 100644
--- a/packages/grafana-data/src/types/datasource.ts
+++ b/packages/grafana-data/src/types/datasource.ts
@@ -142,6 +142,7 @@ export interface DataSourcePluginMeta<T extends KeyValue = {}> extends PluginMet
   unlicensed?: boolean;
   backend?: boolean;
   isBackend?: boolean;
+  multiValueFilterOperators?: boolean;
 }
 
 interface PluginMetaQueryOptions {
diff --git a/packages/grafana-data/src/types/templateVars.ts b/packages/grafana-data/src/types/templateVars.ts
index 14a1cd38fc8..b8d0de9092a 100644
--- a/packages/grafana-data/src/types/templateVars.ts
+++ b/packages/grafana-data/src/types/templateVars.ts
@@ -53,6 +53,7 @@ export interface AdHocVariableFilter {
   key: string;
   operator: string;
   value: string;
+  values?: string[];
   /** @deprecated  */
   condition?: string;
 }
diff --git a/packages/grafana-prometheus/src/datasource.ts b/packages/grafana-prometheus/src/datasource.ts
index 7c3dee6a3ea..637e701507d 100644
--- a/packages/grafana-prometheus/src/datasource.ts
+++ b/packages/grafana-prometheus/src/datasource.ts
@@ -603,7 +603,7 @@ export class PrometheusDatasource
       return this.languageProvider.getLabelKeys().map((k) => ({ value: k, text: k }));
     }
 
-    const labelFilters: QueryBuilderLabelFilter[] = options.filters.map((f) => ({
+    const labelFilters: QueryBuilderLabelFilter[] = options.filters.map(remapOneOf).map((f) => ({
       label: f.key,
       value: f.value,
       op: f.operator,
@@ -620,7 +620,7 @@ export class PrometheusDatasource
 
   // By implementing getTagKeys and getTagValues we add ad-hoc filters functionality
   async getTagValues(options: DataSourceGetTagValuesOptions<PromQuery>) {
-    const labelFilters: QueryBuilderLabelFilter[] = options.filters.map((f) => ({
+    const labelFilters: QueryBuilderLabelFilter[] = options.filters.map(remapOneOf).map((f) => ({
       label: f.key,
       value: f.value,
       op: f.operator,
@@ -822,7 +822,7 @@ export class PrometheusDatasource
       return [];
     }
 
-    return filters.map((f) => ({
+    return filters.map(remapOneOf).map((f) => ({
       ...f,
       value: this.templateSrv.replace(f.value, {}, this.interpolateQueryExpr),
       operator: scopeFilterOperatorMap[f.operator],
@@ -834,7 +834,7 @@ export class PrometheusDatasource
       return expr;
     }
 
-    const finalQuery = filters.reduce((acc, filter) => {
+    const finalQuery = filters.map(remapOneOf).reduce((acc, filter) => {
       const { key, operator } = filter;
       let { value } = filter;
       if (operator === '=~' || operator === '!~') {
@@ -1001,3 +1001,19 @@ export function prometheusRegularEscape<T>(value: T) {
 export function prometheusSpecialRegexEscape<T>(value: T) {
   return typeof value === 'string' ? value.replace(/\\/g, '\\\\\\\\').replace(/[$^*{}\[\]\'+?.()|]/g, '\\\\$&') : value;
 }
+
+export function remapOneOf(filter: AdHocVariableFilter) {
+  let { operator, value, values } = filter;
+  if (operator === '=|') {
+    operator = '=~';
+    value = values?.map(prometheusRegularEscape).join('|') ?? '';
+  } else if (operator === '!=|') {
+    operator = '!~';
+    value = values?.map(prometheusRegularEscape).join('|') ?? '';
+  }
+  return {
+    ...filter,
+    operator,
+    value,
+  };
+}
diff --git a/pkg/api/frontendsettings.go b/pkg/api/frontendsettings.go
index 9bf8c35ef75..677e8fa98aa 100644
--- a/pkg/api/frontendsettings.go
+++ b/pkg/api/frontendsettings.go
@@ -449,11 +449,12 @@ func (hs *HTTPServer) getFSDataSources(c *contextmodel.ReqContext, availablePlug
 		dsDTO.Preload = plugin.Preload
 		dsDTO.Module = plugin.Module
 		dsDTO.PluginMeta = &plugins.PluginMetaDTO{
-			JSONData:  plugin.JSONData,
-			Signature: plugin.Signature,
-			Module:    plugin.Module,
-			BaseURL:   plugin.BaseURL,
-			Angular:   plugin.Angular,
+			JSONData:                  plugin.JSONData,
+			Signature:                 plugin.Signature,
+			Module:                    plugin.Module,
+			BaseURL:                   plugin.BaseURL,
+			Angular:                   plugin.Angular,
+			MultiValueFilterOperators: plugin.MultiValueFilterOperators,
 		}
 
 		if ds.JsonData == nil {
diff --git a/pkg/plugins/models.go b/pkg/plugins/models.go
index 96974cbcb1b..f08b192062c 100644
--- a/pkg/plugins/models.go
+++ b/pkg/plugins/models.go
@@ -171,13 +171,11 @@ type Signature struct {
 
 type PluginMetaDTO struct {
 	JSONData
-
-	Signature SignatureStatus `json:"signature"`
-
-	Module  string `json:"module"`
-	BaseURL string `json:"baseUrl"`
-
-	Angular AngularMeta `json:"angular"`
+	Signature                 SignatureStatus `json:"signature"`
+	Module                    string          `json:"module"`
+	BaseURL                   string          `json:"baseUrl"`
+	Angular                   AngularMeta     `json:"angular"`
+	MultiValueFilterOperators bool            `json:"multiValueFilterOperators"`
 }
 
 type DataSourceDTO struct {
diff --git a/pkg/plugins/plugins.go b/pkg/plugins/plugins.go
index b52585c46ab..5a91ea24b69 100644
--- a/pkg/plugins/plugins.go
+++ b/pkg/plugins/plugins.go
@@ -112,18 +112,19 @@ type JSONData struct {
 	AutoEnabled bool `json:"autoEnabled"`
 
 	// Datasource settings
-	Annotations  bool            `json:"annotations"`
-	Metrics      bool            `json:"metrics"`
-	Alerting     bool            `json:"alerting"`
-	Explore      bool            `json:"explore"`
-	Table        bool            `json:"tables"`
-	Logs         bool            `json:"logs"`
-	Tracing      bool            `json:"tracing"`
-	QueryOptions map[string]bool `json:"queryOptions,omitempty"`
-	BuiltIn      bool            `json:"builtIn,omitempty"`
-	Mixed        bool            `json:"mixed,omitempty"`
-	Streaming    bool            `json:"streaming"`
-	SDK          bool            `json:"sdk,omitempty"`
+	Annotations               bool            `json:"annotations"`
+	Metrics                   bool            `json:"metrics"`
+	Alerting                  bool            `json:"alerting"`
+	Explore                   bool            `json:"explore"`
+	Table                     bool            `json:"tables"`
+	Logs                      bool            `json:"logs"`
+	Tracing                   bool            `json:"tracing"`
+	QueryOptions              map[string]bool `json:"queryOptions,omitempty"`
+	BuiltIn                   bool            `json:"builtIn,omitempty"`
+	Mixed                     bool            `json:"mixed,omitempty"`
+	Streaming                 bool            `json:"streaming"`
+	SDK                       bool            `json:"sdk,omitempty"`
+	MultiValueFilterOperators bool            `json:"multiValueFilterOperators,omitempty"`
 
 	// Backend (Datasource + Renderer + SecretsManager)
 	Executable string `json:"executable,omitempty"`
diff --git a/public/app/features/dashboard-scene/scene/setDashboardPanelContext.ts b/public/app/features/dashboard-scene/scene/setDashboardPanelContext.ts
index dbbf225c129..b40a86b3618 100644
--- a/public/app/features/dashboard-scene/scene/setDashboardPanelContext.ts
+++ b/public/app/features/dashboard-scene/scene/setDashboardPanelContext.ts
@@ -1,4 +1,5 @@
 import { AnnotationChangeEvent, AnnotationEventUIModel, CoreApp, DataFrame } from '@grafana/data';
+import { getDataSourceSrv } from '@grafana/runtime';
 import { AdHocFiltersVariable, dataLayers, sceneGraph, sceneUtils, VizPanel } from '@grafana/scenes';
 import { DataSourceRef } from '@grafana/schema';
 import { AdHocFilterItem, PanelContext } from '@grafana/ui';
@@ -160,6 +161,7 @@ export function getAdHocFilterVariableFor(scene: DashboardScene, ds: DataSourceR
   const newVariable = new AdHocFiltersVariable({
     name: 'Filters',
     datasource: ds,
+    supportsMultiValueOperators: Boolean(getDataSourceSrv().getInstanceSettings(ds)?.meta.multiValueFilterOperators),
     useQueriesAsFilterForOptions: true,
   });
 
diff --git a/public/app/features/dashboard-scene/serialization/transformSceneToSaveModel.test.ts b/public/app/features/dashboard-scene/serialization/transformSceneToSaveModel.test.ts
index 9b02fcc2f6a..042d2cd2ce7 100644
--- a/public/app/features/dashboard-scene/serialization/transformSceneToSaveModel.test.ts
+++ b/public/app/features/dashboard-scene/serialization/transformSceneToSaveModel.test.ts
@@ -136,6 +136,8 @@ jest.mock('@grafana/runtime', () => ({
         toDataQuery: (q: StandardVariableQuery) => q,
       },
     }),
+    // mock getInstanceSettings()
+    getInstanceSettings: jest.fn(),
   }),
   getRunRequest: () => (ds: DataSourceApi, request: DataQueryRequest) => {
     return runRequestMock(ds, request);
diff --git a/public/app/features/dashboard-scene/settings/variables/editors/AdHocFiltersVariableEditor.tsx b/public/app/features/dashboard-scene/settings/variables/editors/AdHocFiltersVariableEditor.tsx
index 5e5ff504462..f165818ebfe 100644
--- a/public/app/features/dashboard-scene/settings/variables/editors/AdHocFiltersVariableEditor.tsx
+++ b/public/app/features/dashboard-scene/settings/variables/editors/AdHocFiltersVariableEditor.tsx
@@ -28,6 +28,7 @@ export function AdHocFiltersVariableEditor(props: AdHocFiltersVariableEditorProp
 
     variable.setState({
       datasource: dsRef,
+      supportsMultiValueOperators: ds.meta.multiValueFilterOperators,
     });
   };
 
diff --git a/public/app/features/dashboard-scene/utils/variables.test.ts b/public/app/features/dashboard-scene/utils/variables.test.ts
index cc97261c95b..0f3616b2f75 100644
--- a/public/app/features/dashboard-scene/utils/variables.test.ts
+++ b/public/app/features/dashboard-scene/utils/variables.test.ts
@@ -26,6 +26,14 @@ import { NEW_LINK } from '../settings/links/utils';
 
 import { createSceneVariableFromVariableModel, createVariablesForSnapshot } from './variables';
 
+// mock getDataSourceSrv.getInstanceSettings()
+jest.mock('@grafana/runtime', () => ({
+  ...jest.requireActual('@grafana/runtime'),
+  getDataSourceSrv: () => ({
+    getInstanceSettings: jest.fn(),
+  }),
+}));
+
 describe('when creating variables objects', () => {
   it('should migrate custom variable', () => {
     const variable: CustomVariableModel = {
@@ -425,6 +433,7 @@ describe('when creating variables objects', () => {
       datasource: { uid: 'gdev-prometheus', type: 'prometheus' },
       applyMode: 'auto',
       useQueriesAsFilterForOptions: true,
+      supportsMultiValueOperators: false,
     });
   });
 
@@ -508,6 +517,7 @@ describe('when creating variables objects', () => {
         },
       ],
       useQueriesAsFilterForOptions: true,
+      supportsMultiValueOperators: false,
     });
   });
 
diff --git a/public/app/features/dashboard-scene/utils/variables.ts b/public/app/features/dashboard-scene/utils/variables.ts
index 3eefdc84fc3..69d15d9daed 100644
--- a/public/app/features/dashboard-scene/utils/variables.ts
+++ b/public/app/features/dashboard-scene/utils/variables.ts
@@ -1,5 +1,5 @@
 import { TypedVariableModel } from '@grafana/data';
-import { config } from '@grafana/runtime';
+import { config, getDataSourceSrv } from '@grafana/runtime';
 import {
   AdHocFiltersVariable,
   ConstantVariable,
@@ -56,6 +56,9 @@ export function createVariablesForSnapshot(oldModel: DashboardModel) {
             baseFilters: v.baseFilters ?? [],
             defaultKeys: v.defaultKeys,
             useQueriesAsFilterForOptions: true,
+            supportsMultiValueOperators: Boolean(
+              getDataSourceSrv().getInstanceSettings(v.datasource)?.meta.multiValueFilterOperators
+            ),
           });
         }
         // for other variable types we are using the SnapshotVariable
@@ -133,6 +136,9 @@ export function createSceneVariableFromVariableModel(variable: TypedVariableMode
       baseFilters: variable.baseFilters ?? [],
       defaultKeys: variable.defaultKeys,
       useQueriesAsFilterForOptions: true,
+      supportsMultiValueOperators: Boolean(
+        getDataSourceSrv().getInstanceSettings(variable.datasource)?.meta.multiValueFilterOperators
+      ),
     });
   }
   if (variable.type === 'custom') {
diff --git a/public/app/features/trails/DataTrail.tsx b/public/app/features/trails/DataTrail.tsx
index 2168b2682f8..76aaf11db4b 100644
--- a/public/app/features/trails/DataTrail.tsx
+++ b/public/app/features/trails/DataTrail.tsx
@@ -262,6 +262,8 @@ function getVariableSet(initialDS?: string, metric?: string, initialFilters?: Ad
         layout: 'vertical',
         filters: initialFilters ?? [],
         baseFilters: getBaseFiltersForMetric(metric),
+        // since we only support prometheus datasources, this is always true
+        supportsMultiValueOperators: true,
       }),
     ],
   });
diff --git a/public/app/plugins/datasource/prometheus/plugin.json b/public/app/plugins/datasource/prometheus/plugin.json
index c11bd2e9809..9f4cf3c82e1 100644
--- a/public/app/plugins/datasource/prometheus/plugin.json
+++ b/public/app/plugins/datasource/prometheus/plugin.json
@@ -89,6 +89,7 @@
   "queryOptions": {
     "minInterval": true
   },
+  "multiValueFilterOperators": true,
   "info": {
     "description": "Open source time series database & alerting",
     "author": {
diff --git a/yarn.lock b/yarn.lock
index 8cf30d396fe..f7bf01c0297 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -3918,9 +3918,9 @@ __metadata:
   languageName: unknown
   linkType: soft
 
-"@grafana/scenes@npm:^5.10.1":
-  version: 5.10.2
-  resolution: "@grafana/scenes@npm:5.10.2"
+"@grafana/scenes@npm:^5.11.0":
+  version: 5.11.0
+  resolution: "@grafana/scenes@npm:5.11.0"
   dependencies:
     "@grafana/e2e-selectors": "npm:^11.0.0"
     "@leeoniya/ufuzzy": "npm:^1.0.14"
@@ -3935,7 +3935,7 @@ __metadata:
     "@grafana/ui": ">=10.4"
     react: ^18.0.0
     react-dom: ^18.0.0
-  checksum: 10/f7409cc8b7d3687baba7d5af307fd3f836579f20a71e0a782841ba7031d786a2b039757d0e89822af650e825c6b6102571b524a7f24179002da02d2eeaa3cc8b
+  checksum: 10/4b56c0c831468651f75992979820541c07d3e9cfcb2547c58aed647a60ad02bd8d81b68d233c2ecc401f5b6400e7c29cbe9408f6f5e374bb30161d47ab0f08e2
   languageName: node
   linkType: hard
 
@@ -18495,7 +18495,7 @@ __metadata:
     "@grafana/prometheus": "workspace:*"
     "@grafana/runtime": "workspace:*"
     "@grafana/saga-icons": "workspace:*"
-    "@grafana/scenes": "npm:^5.10.1"
+    "@grafana/scenes": "npm:^5.11.0"
     "@grafana/schema": "workspace:*"
     "@grafana/sql": "workspace:*"
     "@grafana/tsconfig": "npm:^2.0.0"