diff --git a/package.json b/package.json
index 5cd820d1c6a..ae971addd8b 100644
--- a/package.json
+++ b/package.json
@@ -225,8 +225,7 @@
     "webpack-cleanup-plugin": "0.5.1",
     "webpack-cli": "4.9.0",
     "webpack-dev-server": "4.3.1",
-    "webpack-merge": "5.8.0",
-    "worker-loader": "^3.0.8"
+    "webpack-merge": "5.8.0"
   },
   "dependencies": {
     "@emotion/css": "11.1.3",
@@ -269,6 +268,7 @@
     "centrifuge": "2.7.5",
     "classnames": "2.2.6",
     "clipboard": "2.0.4",
+    "comlink": "4.3.1",
     "common-tags": "^1.8.0",
     "core-js": "3.10.0",
     "d3": "5.15.0",
diff --git a/packages/grafana-runtime/src/index.ts b/packages/grafana-runtime/src/index.ts
index 68b0a07cf44..6d30d2d1cf3 100644
--- a/packages/grafana-runtime/src/index.ts
+++ b/packages/grafana-runtime/src/index.ts
@@ -17,12 +17,12 @@ export {
   StreamOptionsProvider,
 } from './utils/DataSourceWithBackend';
 export {
-  toDataQueryError,
   toDataQueryResponse,
   frameToMetricFindValue,
   BackendDataSourceResponse,
   DataResponse,
 } from './utils/queryResponse';
+export { toDataQueryError } from './utils/toDataQueryError';
 export { PanelRenderer, PanelRendererProps, PanelRendererType, setPanelRenderer } from './components/PanelRenderer';
 export { setQueryRunnerFactory, createQueryRunner, QueryRunnerFactory } from './services/QueryRunner';
 export { DataSourcePicker, DataSourcePickerProps, DataSourcePickerState } from './components/DataSourcePicker';
diff --git a/packages/grafana-runtime/src/utils/queryResponse.ts b/packages/grafana-runtime/src/utils/queryResponse.ts
index 1acf15de5a8..55c12a20703 100644
--- a/packages/grafana-runtime/src/utils/queryResponse.ts
+++ b/packages/grafana-runtime/src/utils/queryResponse.ts
@@ -14,6 +14,7 @@ import {
   dataFrameFromJSON,
 } from '@grafana/data';
 import { FetchError, FetchResponse } from '../services';
+import { toDataQueryError } from './toDataQueryError';
 
 /**
  * Single response object from a backend data source. Properties are optional but response should contain at least
@@ -159,36 +160,6 @@ export function toTestingStatus(err: FetchError): any {
   throw err;
 }
 
-/**
- * Convert an object into a DataQueryError -- if this is an HTTP response,
- * it will put the correct values in the error field
- *
- * @public
- */
-export function toDataQueryError(err: DataQueryError | string | Object): DataQueryError {
-  const error = (err || {}) as DataQueryError;
-
-  if (!error.message) {
-    if (typeof err === 'string' || err instanceof String) {
-      return { message: err } as DataQueryError;
-    }
-
-    let message = 'Query error';
-    if (error.message) {
-      message = error.message;
-    } else if (error.data && error.data.message) {
-      message = error.data.message;
-    } else if (error.data && error.data.error) {
-      message = error.data.error;
-    } else if (error.status) {
-      message = `Query error: ${error.status} ${error.statusText}`;
-    }
-    error.message = message;
-  }
-
-  return error;
-}
-
 /**
  * Return the first string or non-time field as the value
  *
diff --git a/packages/grafana-runtime/src/utils/toDataQueryError.ts b/packages/grafana-runtime/src/utils/toDataQueryError.ts
new file mode 100644
index 00000000000..f616195a472
--- /dev/null
+++ b/packages/grafana-runtime/src/utils/toDataQueryError.ts
@@ -0,0 +1,31 @@
+import { DataQueryError } from '@grafana/data';
+
+/**
+ * Convert an object into a DataQueryError -- if this is an HTTP response,
+ * it will put the correct values in the error field
+ *
+ * @public
+ */
+export function toDataQueryError(err: DataQueryError | string | Object): DataQueryError {
+  const error = (err || {}) as DataQueryError;
+
+  if (!error.message) {
+    if (typeof err === 'string' || err instanceof String) {
+      return { message: err } as DataQueryError;
+    }
+
+    let message = 'Query error';
+    if (error.message) {
+      message = error.message;
+    } else if (error.data && error.data.message) {
+      message = error.data.message;
+    } else if (error.data && error.data.error) {
+      message = error.data.error;
+    } else if (error.status) {
+      message = `Query error: ${error.status} ${error.statusText}`;
+    }
+    error.message = message;
+  }
+
+  return error;
+}
diff --git a/public/app/core/utils/CorsWorker.ts b/public/app/core/utils/CorsWorker.ts
new file mode 100644
index 00000000000..4cd2a140e0d
--- /dev/null
+++ b/public/app/core/utils/CorsWorker.ts
@@ -0,0 +1,23 @@
+// works with webpack plugin: scripts/webpack/plugins/CorsWorkerPlugin.js
+export class CorsWorker extends window.Worker {
+  constructor(url: URL, options?: WorkerOptions) {
+    // by default, worker inherits HTML document's location and pathname which leads to wrong public path value
+    // the CorsWorkerPlugin will override it with the value based on the initial worker chunk, ie.
+    //    initial worker chunk: http://host.com/cdn/scripts/worker-123.js
+    //    resulting public path: http://host.com/cdn/scripts
+
+    const scriptUrl = url.toString();
+    const urlParts = scriptUrl.split('/');
+    urlParts.pop();
+    const scriptsBasePathUrl = `${urlParts.join('/')}/`;
+
+    const importScripts = `importScripts('${scriptUrl}');`;
+    const objectURL = URL.createObjectURL(
+      new Blob([`__webpack_worker_public_path__ = '${scriptsBasePathUrl}'; ${importScripts}`], {
+        type: 'application/javascript',
+      })
+    );
+    super(objectURL, options);
+    URL.revokeObjectURL(objectURL);
+  }
+}
diff --git a/public/app/features/dashboard/dashgrid/liveTimer.ts b/public/app/features/dashboard/dashgrid/liveTimer.ts
index 113e9f64d7b..0631c3ca4db 100644
--- a/public/app/features/dashboard/dashgrid/liveTimer.ts
+++ b/public/app/features/dashboard/dashgrid/liveTimer.ts
@@ -1,4 +1,5 @@
 import { dateMath, dateTime, TimeRange } from '@grafana/data';
+import { BehaviorSubject } from 'rxjs';
 import { PanelChrome } from './PanelChrome';
 
 // target is 20hz (50ms), but we poll at 100ms to smooth out jitter
@@ -15,7 +16,7 @@ class LiveTimer {
 
   budget = 1;
   threshold = 1.5; // trial and error appears about right
-  ok = true;
+  ok = new BehaviorSubject(true);
   lastUpdate = Date.now();
 
   isLive = false; // the dashboard time range ends in "now"
@@ -69,11 +70,16 @@ class LiveTimer {
   measure = () => {
     const now = Date.now();
     this.budget = (now - this.lastUpdate) / interval;
-    this.ok = this.budget <= this.threshold;
+
+    const oldOk = this.ok.getValue();
+    const newOk = this.budget <= this.threshold;
+    if (oldOk !== newOk) {
+      this.ok.next(newOk);
+    }
     this.lastUpdate = now;
 
     // For live dashboards, listen to changes
-    if (this.ok && this.isLive && this.timeRange) {
+    if (this.isLive && this.ok.getValue() && this.timeRange) {
       // when the time-range is relative fire events
       let tr: TimeRange | undefined = undefined;
       for (const listener of this.listeners) {
diff --git a/public/app/features/explore/NodeGraphContainer.test.tsx b/public/app/features/explore/NodeGraphContainer.test.tsx
index 2441fd795a2..2560771fd8d 100644
--- a/public/app/features/explore/NodeGraphContainer.test.tsx
+++ b/public/app/features/explore/NodeGraphContainer.test.tsx
@@ -3,7 +3,6 @@ import { render, screen } from '@testing-library/react';
 import { UnconnectedNodeGraphContainer } from './NodeGraphContainer';
 import { getDefaultTimeRange, MutableDataFrame } from '@grafana/data';
 import { ExploreId } from '../../types';
-jest.mock('../../plugins/panel/nodeGraph/layout.worker.js');
 
 describe('NodeGraphContainer', () => {
   it('is collapsed if shown with traces', () => {
diff --git a/public/app/features/live/centrifuge/createCentrifugeServiceWorker.ts b/public/app/features/live/centrifuge/createCentrifugeServiceWorker.ts
new file mode 100644
index 00000000000..c7c68f5b0e7
--- /dev/null
+++ b/public/app/features/live/centrifuge/createCentrifugeServiceWorker.ts
@@ -0,0 +1,3 @@
+import { CorsWorker as Worker } from 'app/core/utils/CorsWorker';
+
+export const createWorker = () => new Worker(new URL('./service.worker.ts', import.meta.url));
diff --git a/public/app/features/live/centrifuge/remoteObservable.ts b/public/app/features/live/centrifuge/remoteObservable.ts
new file mode 100644
index 00000000000..bacca066355
--- /dev/null
+++ b/public/app/features/live/centrifuge/remoteObservable.ts
@@ -0,0 +1,33 @@
+import * as comlink from 'comlink';
+import { from, Observable, switchMap } from 'rxjs';
+
+export const remoteObservableAsObservable = <T>(remoteObs: comlink.RemoteObject<Observable<T>>): Observable<T> =>
+  new Observable((subscriber) => {
+    // Passing the callbacks as 3 separate arguments is deprecated, but it's the only option for now
+    //
+    // RxJS recreates the functions via `Function.bind` https://github.com/ReactiveX/rxjs/blob/62aca850a37f598b5db6085661e0594b81ec4281/src/internal/Subscriber.ts#L169
+    // and thus erases the ProxyMarker created via comlink.proxy(fN) when the callbacks
+    // are grouped together in a Observer object (ie. { next: (v) => ..., error: (err) => ..., complete: () => ... })
+    //
+    // solution: TBD (autoproxy all functions?)
+    const remoteSubPromise = remoteObs.subscribe(
+      comlink.proxy((nextValueInRemoteObs: T) => {
+        subscriber.next(nextValueInRemoteObs);
+      }),
+      comlink.proxy((err) => {
+        subscriber.error(err);
+      }),
+      comlink.proxy(() => {
+        subscriber.complete();
+      })
+    );
+    return {
+      unsubscribe: () => {
+        remoteSubPromise.then((remoteSub) => remoteSub.unsubscribe());
+      },
+    };
+  });
+
+export const promiseWithRemoteObservableAsObservable = <T>(
+  promiseWithProxyObservable: Promise<comlink.RemoteObject<Observable<T>>>
+): Observable<T> => from(promiseWithProxyObservable).pipe(switchMap((val) => remoteObservableAsObservable(val)));
diff --git a/public/app/features/live/centrifuge/service.ts b/public/app/features/live/centrifuge/service.ts
index 3b738c28245..71e35022dcc 100644
--- a/public/app/features/live/centrifuge/service.ts
+++ b/public/app/features/live/centrifuge/service.ts
@@ -1,5 +1,6 @@
 import Centrifuge from 'centrifuge/dist/centrifuge';
-import { LiveDataStreamOptions, toDataQueryError } from '@grafana/runtime';
+import { LiveDataStreamOptions } from '@grafana/runtime';
+import { toDataQueryError } from '@grafana/runtime/src/utils/toDataQueryError';
 import { BehaviorSubject, Observable } from 'rxjs';
 import {
   DataFrame,
@@ -15,25 +16,52 @@ import {
   LiveChannelPresenceStatus,
   LoadingState,
   StreamingDataFrame,
+  toDataFrameDTO,
 } from '@grafana/data';
 import { CentrifugeLiveChannel } from './channel';
-import { liveTimer } from 'app/features/dashboard/dashgrid/liveTimer';
 
-type CentrifugeSrvDeps = {
+export type CentrifugeSrvDeps = {
   appUrl: string;
   orgId: number;
   orgRole: string;
   sessionId: string;
   liveEnabled: boolean;
+  dataStreamSubscriberReadiness: Observable<boolean>;
 };
 
-export class CentrifugeSrv {
+export interface CentrifugeSrv {
+  /**
+   * Listen for changes to the connection state
+   */
+  getConnectionState(): Observable<boolean>;
+
+  /**
+   * Watch for messages in a channel
+   */
+  getStream<T>(address: LiveChannelAddress, config: LiveChannelConfig): Observable<LiveChannelEvent<T>>;
+
+  /**
+   * Connect to a channel and return results as DataFrames
+   */
+  getDataStream(options: LiveDataStreamOptions, config: LiveChannelConfig): Observable<DataQueryResponse>;
+
+  /**
+   * For channels that support presence, this will request the current state from the server.
+   *
+   * Join and leave messages will be sent to the open stream
+   */
+  getPresence(address: LiveChannelAddress, config: LiveChannelConfig): Promise<LiveChannelPresenceStatus>;
+}
+
+export class CentrifugeService implements CentrifugeSrv {
   readonly open = new Map<string, CentrifugeLiveChannel>();
   readonly centrifuge: Centrifuge;
   readonly connectionState: BehaviorSubject<boolean>;
   readonly connectionBlocker: Promise<void>;
+  private dataStreamSubscriberReady = true;
 
   constructor(private deps: CentrifugeSrvDeps) {
+    deps.dataStreamSubscriberReadiness.subscribe((next) => (this.dataStreamSubscriberReady = next));
     const liveUrl = `${deps.appUrl.replace(/^http/, 'ws')}/api/live/ws`;
     this.centrifuge = new Centrifuge(liveUrl, {});
     this.centrifuge.setConnectData({
@@ -66,15 +94,15 @@ export class CentrifugeSrv {
   // Internal functions
   //----------------------------------------------------------
 
-  onConnect = (context: any) => {
+  private onConnect = (context: any) => {
     this.connectionState.next(true);
   };
 
-  onDisconnect = (context: any) => {
+  private onDisconnect = (context: any) => {
     this.connectionState.next(false);
   };
 
-  onServerSideMessage = (context: any) => {
+  private onServerSideMessage = (context: any) => {
     console.log('Publication from server-side channel', context);
   };
 
@@ -82,7 +110,7 @@ export class CentrifugeSrv {
    * Get a channel.  If the scope, namespace, or path is invalid, a shutdown
    * channel will be returned with an error state indicated in its status
    */
-  getChannel<TMessage>(addr: LiveChannelAddress, config: LiveChannelConfig): CentrifugeLiveChannel<TMessage> {
+  private getChannel<TMessage>(addr: LiveChannelAddress, config: LiveChannelConfig): CentrifugeLiveChannel<TMessage> {
     const id = `${this.deps.orgId}/${addr.scope}/${addr.namespace}/${addr.path}`;
     let channel = this.open.get(id);
     if (channel != null) {
@@ -145,7 +173,6 @@ export class CentrifugeSrv {
       let data: StreamingDataFrame | undefined = undefined;
       let filtered: DataFrame | undefined = undefined;
       let state = LoadingState.Streaming;
-      let last = liveTimer.lastUpdate;
       let lastWidth = -1;
 
       const process = (msg: DataFrameJSON) => {
@@ -172,11 +199,18 @@ export class CentrifugeSrv {
           }
         }
 
-        const elapsed = liveTimer.lastUpdate - last;
-        if (elapsed > 1000 || liveTimer.ok) {
+        if (this.dataStreamSubscriberReady) {
           filtered.length = data.length; // make sure they stay up-to-date
-          subscriber.next({ state, data: [filtered], key });
-          last = liveTimer.lastUpdate;
+          subscriber.next({
+            state,
+            data: [
+              // workaround for serializing issues when sending DataFrame from web worker to the main thread
+              // DataFrame is making use of ArrayVectors which are es6 classes and thus not cloneable out of the box
+              // `toDataFrameDTO` converts ArrayVectors into native arrays.
+              toDataFrameDTO(filtered),
+            ],
+            key,
+          });
         }
       };
 
diff --git a/public/app/features/live/centrifuge/service.worker.ts b/public/app/features/live/centrifuge/service.worker.ts
new file mode 100644
index 00000000000..e3ce9d19405
--- /dev/null
+++ b/public/app/features/live/centrifuge/service.worker.ts
@@ -0,0 +1,52 @@
+import { CentrifugeService, CentrifugeSrvDeps } from './service';
+import * as comlink from 'comlink';
+import './transferHandlers';
+import { remoteObservableAsObservable } from './remoteObservable';
+import { LiveChannelAddress, LiveChannelConfig } from '@grafana/data';
+import { LiveDataStreamOptions } from '@grafana/runtime';
+
+let centrifuge: CentrifugeService;
+
+const initialize = (
+  deps: CentrifugeSrvDeps,
+  remoteDataStreamSubscriberReadiness: comlink.RemoteObject<
+    CentrifugeSrvDeps['dataStreamSubscriberReadiness'] & comlink.ProxyMarked
+  >
+) => {
+  centrifuge = new CentrifugeService({
+    ...deps,
+    dataStreamSubscriberReadiness: remoteObservableAsObservable(remoteDataStreamSubscriberReadiness),
+  });
+};
+
+const getConnectionState = () => {
+  return comlink.proxy(centrifuge.getConnectionState());
+};
+
+const getDataStream = (options: LiveDataStreamOptions, config: LiveChannelConfig) => {
+  return comlink.proxy(centrifuge.getDataStream(options, config));
+};
+
+const getStream = (address: LiveChannelAddress, config: LiveChannelConfig) => {
+  return comlink.proxy(centrifuge.getStream(address, config));
+};
+
+const getPresence = async (address: LiveChannelAddress, config: LiveChannelConfig) => {
+  return await centrifuge.getPresence(address, config);
+};
+
+const workObj = {
+  initialize,
+  getConnectionState,
+  getDataStream,
+  getStream,
+  getPresence,
+};
+
+export type RemoteCentrifugeService = typeof workObj;
+
+comlink.expose(workObj);
+
+export default class {
+  constructor() {}
+}
diff --git a/public/app/features/live/centrifuge/serviceWorkerProxy.ts b/public/app/features/live/centrifuge/serviceWorkerProxy.ts
new file mode 100644
index 00000000000..a1d5b369567
--- /dev/null
+++ b/public/app/features/live/centrifuge/serviceWorkerProxy.ts
@@ -0,0 +1,40 @@
+import { CentrifugeSrv, CentrifugeSrvDeps } from './service';
+import { RemoteCentrifugeService } from './service.worker';
+import './transferHandlers';
+
+import * as comlink from 'comlink';
+import { asyncScheduler, Observable, observeOn } from 'rxjs';
+import { LiveChannelAddress, LiveChannelConfig, LiveChannelEvent } from '@grafana/data';
+import { promiseWithRemoteObservableAsObservable } from './remoteObservable';
+import { createWorker } from './createCentrifugeServiceWorker';
+
+export class CentrifugeServiceWorkerProxy implements CentrifugeSrv {
+  private centrifugeWorker;
+
+  constructor(deps: CentrifugeSrvDeps) {
+    this.centrifugeWorker = comlink.wrap<RemoteCentrifugeService>(createWorker() as comlink.Endpoint);
+    this.centrifugeWorker.initialize(deps, comlink.proxy(deps.dataStreamSubscriberReadiness));
+  }
+
+  getConnectionState: CentrifugeSrv['getConnectionState'] = () => {
+    return promiseWithRemoteObservableAsObservable(this.centrifugeWorker.getConnectionState());
+  };
+
+  getDataStream: CentrifugeSrv['getDataStream'] = (options, config) => {
+    return promiseWithRemoteObservableAsObservable(this.centrifugeWorker.getDataStream(options, config)).pipe(
+      // async scheduler splits the synchronous task of deserializing data from web worker and
+      // consuming the message (ie. updating react component) into two to avoid blocking the event loop
+      observeOn(asyncScheduler)
+    );
+  };
+
+  getPresence: CentrifugeSrv['getPresence'] = (address, config) => {
+    return this.centrifugeWorker.getPresence(address, config);
+  };
+
+  getStream: CentrifugeSrv['getStream'] = <T>(address: LiveChannelAddress, config: LiveChannelConfig) => {
+    return promiseWithRemoteObservableAsObservable(
+      this.centrifugeWorker.getStream(address, config) as Promise<comlink.Remote<Observable<LiveChannelEvent<T>>>>
+    );
+  };
+}
diff --git a/public/app/features/live/centrifuge/transferHandlers.ts b/public/app/features/live/centrifuge/transferHandlers.ts
new file mode 100644
index 00000000000..f42cc3f75de
--- /dev/null
+++ b/public/app/features/live/centrifuge/transferHandlers.ts
@@ -0,0 +1,27 @@
+import * as comlink from 'comlink';
+import { Subscriber } from 'rxjs';
+
+// Observers, ie. functions passed to `observable.subscribe(...)`, are converted to a subclass of `Subscriber` before they are sent to the source Observable.
+// The conversion happens internally in the RxJS library - this transfer handler is catches them and wraps them with a proxy
+const subscriberTransferHandler: any = {
+  canHandle(value: any): boolean {
+    return value && value instanceof Subscriber;
+  },
+
+  serialize(value: Function): [MessagePort, Transferable[]] {
+    const obj = comlink.proxy(value);
+
+    const { port1, port2 } = new MessageChannel();
+
+    comlink.expose(obj, port1);
+
+    return [port2, [port2]];
+  },
+
+  deserialize(value: MessagePort): comlink.Remote<MessagePort> {
+    value.start();
+
+    return comlink.wrap<MessagePort>(value);
+  },
+};
+comlink.transferHandlers.set('SubscriberHandler', subscriberTransferHandler);
diff --git a/public/app/features/live/index.ts b/public/app/features/live/index.ts
index 8d9b8e5a7f5..12b7baca0c9 100644
--- a/public/app/features/live/index.ts
+++ b/public/app/features/live/index.ts
@@ -1,10 +1,12 @@
 import { config, getBackendSrv, getGrafanaLiveSrv, setGrafanaLiveSrv } from '@grafana/runtime';
-import { CentrifugeSrv } from './centrifuge/service';
 import { registerLiveFeatures } from './features';
 import { GrafanaLiveService } from './live';
 import { GrafanaLiveChannelConfigService } from './channel-config';
 import { GrafanaLiveChannelConfigSrv } from './channel-config/types';
 import { contextSrv } from '../../core/services/context_srv';
+import { CentrifugeServiceWorkerProxy } from './centrifuge/serviceWorkerProxy';
+import { CentrifugeService } from './centrifuge/service';
+import { liveTimer } from 'app/features/dashboard/dashgrid/liveTimer';
 
 const grafanaLiveScopesSingleton = new GrafanaLiveChannelConfigService();
 
@@ -18,13 +20,19 @@ export const sessionId =
   Math.random().toString(36).substring(2, 15);
 
 export function initGrafanaLive() {
-  const centrifugeSrv = new CentrifugeSrv({
+  const centrifugeServiceDeps = {
     appUrl: `${window.location.origin}${config.appSubUrl}`,
     orgId: contextSrv.user.orgId,
     orgRole: contextSrv.user.orgRole,
     liveEnabled: config.liveEnabled,
     sessionId,
-  });
+    dataStreamSubscriberReadiness: liveTimer.ok.asObservable(),
+  };
+
+  const centrifugeSrv = config.featureToggles['live-service-web-worker']
+    ? new CentrifugeServiceWorkerProxy(centrifugeServiceDeps)
+    : new CentrifugeService(centrifugeServiceDeps);
+
   setGrafanaLiveSrv(
     new GrafanaLiveService({
       scopes: getGrafanaLiveScopes(),
diff --git a/public/app/plugins/panel/nodeGraph/NodeGraph.test.tsx b/public/app/plugins/panel/nodeGraph/NodeGraph.test.tsx
index 19b562191dc..2f530436669 100644
--- a/public/app/plugins/panel/nodeGraph/NodeGraph.test.tsx
+++ b/public/app/plugins/panel/nodeGraph/NodeGraph.test.tsx
@@ -3,7 +3,6 @@ import { render, screen, fireEvent, waitFor, getByText } from '@testing-library/
 import userEvent from '@testing-library/user-event';
 import { NodeGraph } from './NodeGraph';
 import { makeEdgesDataFrame, makeNodesDataFrame } from './utils';
-jest.mock('./layout.worker.js');
 
 jest.mock('react-use/lib/useMeasure', () => {
   return {
diff --git a/public/app/plugins/panel/nodeGraph/__mocks__/layout.worker.js b/public/app/plugins/panel/nodeGraph/__mocks__/layout.worker.js
deleted file mode 100644
index 39c401010e6..00000000000
--- a/public/app/plugins/panel/nodeGraph/__mocks__/layout.worker.js
+++ /dev/null
@@ -1,12 +0,0 @@
-const { layout } = jest.requireActual('../layout.worker.js');
-
-export default class TestWorker {
-  constructor() {}
-  postMessage(data) {
-    const { nodes, edges, config } = data;
-    setTimeout(() => {
-      layout(nodes, edges, config);
-      this.onmessage({ data: { nodes, edges } });
-    }, 1);
-  }
-}
diff --git a/public/app/plugins/panel/nodeGraph/createLayoutWorker.ts b/public/app/plugins/panel/nodeGraph/createLayoutWorker.ts
new file mode 100644
index 00000000000..1aa1f1e9083
--- /dev/null
+++ b/public/app/plugins/panel/nodeGraph/createLayoutWorker.ts
@@ -0,0 +1,3 @@
+import { CorsWorker as Worker } from 'app/core/utils/CorsWorker';
+
+export const createWorker = () => new Worker(new URL('./layout.worker.js', import.meta.url));
diff --git a/public/app/plugins/panel/nodeGraph/layout.ts b/public/app/plugins/panel/nodeGraph/layout.ts
index 6087c04f6f2..4814de573da 100644
--- a/public/app/plugins/panel/nodeGraph/layout.ts
+++ b/public/app/plugins/panel/nodeGraph/layout.ts
@@ -4,8 +4,7 @@ import { Field } from '@grafana/data';
 import { useNodeLimit } from './useNodeLimit';
 import useMountedState from 'react-use/lib/useMountedState';
 import { graphBounds } from './utils';
-// @ts-ignore
-import LayoutWorker from './layout.worker.js';
+import { createWorker } from './createLayoutWorker';
 
 export interface Config {
   linkDistance: number;
@@ -135,7 +134,7 @@ function defaultLayout(
   edges: EdgeDatum[],
   done: (data: { nodes: NodeDatum[]; edges: EdgeDatum[] }) => void
 ) {
-  const worker = new LayoutWorker();
+  const worker = createWorker();
   worker.onmessage = (event: MessageEvent<{ nodes: NodeDatum[]; edges: EdgeDatumLayout[] }>) => {
     for (let i = 0; i < nodes.length; i++) {
       // These stats needs to be Field class but the data is stringified over the worker boundary
diff --git a/public/test/jest-setup.ts b/public/test/jest-setup.ts
index 8b505d5ff00..40a7a0ceffa 100644
--- a/public/test/jest-setup.ts
+++ b/public/test/jest-setup.ts
@@ -3,6 +3,7 @@ import { EventBusSrv } from '@grafana/data';
 import Adapter from '@wojtekmaj/enzyme-adapter-react-17';
 import $ from 'jquery';
 import 'mutationobserver-shim';
+import './mocks/workers';
 
 const testAppEvents = new EventBusSrv();
 const global = window as any;
diff --git a/public/test/mocks/workers.ts b/public/test/mocks/workers.ts
new file mode 100644
index 00000000000..c21cee96220
--- /dev/null
+++ b/public/test/mocks/workers.ts
@@ -0,0 +1,27 @@
+const { layout } = jest.requireActual('../../app/plugins/panel/nodeGraph/layout.worker.js');
+
+class LayoutMockWorker {
+  constructor() {}
+
+  postMessage(data: any) {
+    const { nodes, edges, config } = data;
+    setTimeout(() => {
+      layout(nodes, edges, config);
+      // @ts-ignore
+      this.onmessage({ data: { nodes, edges } });
+    }, 1);
+  }
+}
+
+jest.mock('../../app/plugins/panel/nodeGraph/createLayoutWorker', () => ({
+  createWorker: () => new LayoutMockWorker(),
+}));
+
+class BasicMockWorker {
+  postMessage() {}
+}
+const mockCreateWorker = {
+  createWorker: () => new BasicMockWorker(),
+};
+
+jest.mock('../../app/features/live/centrifuge/createCentrifugeServiceWorker', () => mockCreateWorker);
diff --git a/scripts/webpack/plugins/CorsWorkerPlugin.js b/scripts/webpack/plugins/CorsWorkerPlugin.js
new file mode 100644
index 00000000000..cc613721de5
--- /dev/null
+++ b/scripts/webpack/plugins/CorsWorkerPlugin.js
@@ -0,0 +1,64 @@
+const { RuntimeGlobals, RuntimeModule } = require('webpack');
+
+class CorsWorkerPublicPathRuntimeModule extends RuntimeModule {
+  constructor(publicPath) {
+    super('publicPath', RuntimeModule.STAGE_BASIC);
+    this.publicPath = publicPath;
+  }
+
+  /**
+   * @returns {string} runtime code
+   */
+  generate() {
+    const { compilation, publicPath } = this;
+
+    const publicPathValue = compilation.getPath(publicPath || '', {
+      hash: compilation.hash || 'XXXX',
+    });
+    return `${RuntimeGlobals.publicPath} = __webpack_worker_public_path__ || '${publicPathValue}';`;
+  }
+}
+
+// https://github.com/webpack/webpack/discussions/14648#discussioncomment-1604202
+// by @ https://github.com/piotr-oles
+class CorsWorkerPlugin {
+  /**
+   * @param {import('webpack').Compiler} compiler
+   */
+  apply(compiler) {
+    compiler.hooks.compilation.tap(
+      'CorsWorkerPlugin',
+      /**
+       * @param {import('webpack').Compilation} compilation
+       */
+      (compilation) => {
+        const getChunkLoading = (chunk) => {
+          const entryOptions = chunk.getEntryOptions();
+          return entryOptions && entryOptions.chunkLoading !== undefined
+            ? entryOptions.chunkLoading
+            : compilation.outputOptions.chunkLoading;
+        };
+        const getChunkPublicPath = (chunk) => {
+          const entryOptions = chunk.getEntryOptions();
+          return entryOptions && entryOptions.publicPath !== undefined
+            ? entryOptions.publicPath
+            : compilation.outputOptions.publicPath;
+        };
+
+        compilation.hooks.runtimeRequirementInTree.for(RuntimeGlobals.publicPath).tap('CorsWorkerPlugin', (chunk) => {
+          if (getChunkLoading(chunk) === 'import-scripts') {
+            const publicPath = getChunkPublicPath(chunk);
+
+            if (publicPath !== 'auto') {
+              const module = new CorsWorkerPublicPathRuntimeModule(publicPath);
+              compilation.addRuntimeModule(chunk, module);
+              return true;
+            }
+          }
+        });
+      }
+    );
+  }
+}
+
+module.exports = CorsWorkerPlugin;
diff --git a/scripts/webpack/webpack.common.js b/scripts/webpack/webpack.common.js
index 3e5b66e7e35..13380271bf5 100644
--- a/scripts/webpack/webpack.common.js
+++ b/scripts/webpack/webpack.common.js
@@ -1,7 +1,7 @@
 const fs = require('fs-extra');
 const path = require('path');
 const webpack = require('webpack');
-
+const CorsWorkerPlugin = require('./plugins/CorsWorkerPlugin');
 const CopyWebpackPlugin = require('copy-webpack-plugin');
 
 class CopyUniconsPlugin {
@@ -58,6 +58,7 @@ module.exports = {
     source: false,
   },
   plugins: [
+    new CorsWorkerPlugin(),
     new webpack.ProvidePlugin({
       Buffer: ['buffer', 'Buffer'],
     }),
@@ -124,15 +125,6 @@ module.exports = {
         loader: 'file-loader',
         options: { name: 'static/img/[name].[hash:8].[ext]' },
       },
-      {
-        test: /\.worker\.js$/,
-        use: {
-          loader: 'worker-loader',
-          options: {
-            inline: 'fallback',
-          },
-        },
-      },
     ],
   },
   // https://webpack.js.org/plugins/split-chunks-plugin/#split-chunks-example-3
diff --git a/yarn.lock b/yarn.lock
index b829dd4502c..8817270a48c 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -12355,6 +12355,13 @@ __metadata:
   languageName: node
   linkType: hard
 
+"comlink@npm:4.3.1":
+  version: 4.3.1
+  resolution: "comlink@npm:4.3.1"
+  checksum: 557360a6558708c55aff74a25f834bfb9bfca8a42444682c4d5aead57681534a0206202be2a2760b4de124c3ba6d485b08978b6d5469cb3d26bf1438ee28a4f1
+  languageName: node
+  linkType: hard
+
 "comma-separated-tokens@npm:^1.0.0":
   version: 1.0.8
   resolution: "comma-separated-tokens@npm:1.0.8"
@@ -17829,6 +17836,7 @@ __metadata:
     centrifuge: 2.7.5
     classnames: 2.2.6
     clipboard: 2.0.4
+    comlink: 4.3.1
     common-tags: ^1.8.0
     copy-webpack-plugin: 9.0.1
     core-js: 3.10.0
@@ -17994,7 +18002,6 @@ __metadata:
     webpack-dev-server: 4.3.1
     webpack-merge: 5.8.0
     whatwg-fetch: 3.1.0
-    worker-loader: ^3.0.8
   languageName: unknown
   linkType: soft
 
@@ -33911,18 +33918,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"worker-loader@npm:^3.0.8":
-  version: 3.0.8
-  resolution: "worker-loader@npm:3.0.8"
-  dependencies:
-    loader-utils: ^2.0.0
-    schema-utils: ^3.0.0
-  peerDependencies:
-    webpack: ^4.0.0 || ^5.0.0
-  checksum: 84f4a7eeb2a1d8b9704425837e017c91eedfae67ac89e0b866a2dcf283323c1dcabe0258196278b7d5fd0041392da895c8a0c59ddf3a94f1b2e003df68ddfec3
-  languageName: node
-  linkType: hard
-
 "worker-rpc@npm:^0.1.0":
   version: 0.1.1
   resolution: "worker-rpc@npm:0.1.1"