diff --git a/conference.js b/conference.js
index c9db7b7e56..d9b2187086 100644
--- a/conference.js
+++ b/conference.js
@@ -76,12 +76,16 @@ import {
 import {
     getStartWithAudioMuted,
     getStartWithVideoMuted,
+    isAudioMuted,
+    isVideoMuted,
     isVideoMutedByUser,
     MEDIA_TYPE,
     setAudioAvailable,
     setAudioMuted,
+    setAudioUnmutePermissions,
     setVideoAvailable,
-    setVideoMuted
+    setVideoMuted,
+    setVideoUnmutePermissions
 } from './react/features/base/media';
 import {
     dominantSpeakerChanged,
@@ -2257,6 +2261,27 @@ export default {
             APP.store.dispatch(suspendDetected());
         });
 
+        room.on(
+            JitsiConferenceEvents.AUDIO_UNMUTE_PERMISSIONS_CHANGED,
+            disableAudioMuteChange => {
+                const muted = isAudioMuted(APP.store.getState());
+
+                // Disable the mute button only if its muted.
+                if (!disableAudioMuteChange || (disableAudioMuteChange && muted)) {
+                    APP.store.dispatch(setAudioUnmutePermissions(disableAudioMuteChange));
+                }
+            });
+        room.on(
+            JitsiConferenceEvents.VIDEO_UNMUTE_PERMISSIONS_CHANGED,
+            disableVideoMuteChange => {
+                const muted = isVideoMuted(APP.store.getState());
+
+                // Disable the mute button only if its muted.
+                if (!disableVideoMuteChange || (disableVideoMuteChange && muted)) {
+                    APP.store.dispatch(setVideoUnmutePermissions(disableVideoMuteChange));
+                }
+            });
+
         APP.UI.addListener(UIEvents.AUDIO_MUTED, muted => {
             this.muteAudio(muted);
         });
diff --git a/lang/main.json b/lang/main.json
index 71739aa267..3216ed36ec 100644
--- a/lang/main.json
+++ b/lang/main.json
@@ -572,6 +572,8 @@
     "notify": {
         "allowAction": "Allow",
         "allowedUnmute": "You can unmute your microphone, start your camera or share your screen.",
+        "audioUnmuteBlockedTitle": "Mic unmute blocked!",
+        "audioUnmuteBlockedDescription": "Mic unmute operation has been temporarily blocked because of system limits.",
         "connectedOneMember": "{{name}} joined the meeting",
         "connectedThreePlusMembers": "{{name}} and many others joined the meeting",
         "connectedTwoMembers": "{{first}} and {{second}} joined the meeting",
@@ -622,7 +624,9 @@
         "moderationToggleDescription": "by {{participantDisplayName}}",
         "raiseHandAction": "Raise hand",
         "reactionSounds": "Disable sounds",
-        "groupTitle": "Notifications"
+        "groupTitle": "Notifications",
+        "videoUnmuteBlockedTitle": "Camera unmute blocked!",
+        "videoUnmuteBlockedDescription": "Camera unmute operation has been temporarily blocked because of system limits."
     },
     "participantsPane": {
         "close": "Close",
diff --git a/react/features/base/conference/actions.js b/react/features/base/conference/actions.js
index 6ca9b3f27c..7abc75945a 100644
--- a/react/features/base/conference/actions.js
+++ b/react/features/base/conference/actions.js
@@ -10,7 +10,15 @@ import { endpointMessageReceived } from '../../subtitles';
 import { getReplaceParticipant } from '../config/functions';
 import { JITSI_CONNECTION_CONFERENCE_KEY } from '../connection';
 import { JitsiConferenceEvents } from '../lib-jitsi-meet';
-import { MEDIA_TYPE, setAudioMuted, setVideoMuted } from '../media';
+import {
+    MEDIA_TYPE,
+    isAudioMuted,
+    isVideoMuted,
+    setAudioMuted,
+    setAudioUnmutePermissions,
+    setVideoMuted,
+    setVideoUnmutePermissions
+} from '../media';
 import {
     dominantSpeakerChanged,
     getNormalizedDisplayName,
@@ -146,6 +154,27 @@ function _addConferenceListeners(conference, dispatch, state) {
             }
         });
 
+    conference.on(
+        JitsiConferenceEvents.AUDIO_UNMUTE_PERMISSIONS_CHANGED,
+        disableAudioMuteChange => {
+            const muted = isAudioMuted(state);
+
+            // Disable the mute button only if its muted.
+            if (!disableAudioMuteChange || (disableAudioMuteChange && muted)) {
+                APP.store.dispatch(setAudioUnmutePermissions(disableAudioMuteChange));
+            }
+        });
+    conference.on(
+        JitsiConferenceEvents.VIDEO_UNMUTE_PERMISSIONS_CHANGED,
+        disableVideoMuteChange => {
+            const muted = isVideoMuted(state);
+
+            // Disable the mute button only if its muted.
+            if (!disableVideoMuteChange || (disableVideoMuteChange && muted)) {
+                APP.store.dispatch(setVideoUnmutePermissions(disableVideoMuteChange));
+            }
+        });
+
     // Dispatches into features/base/tracks follow:
 
     conference.on(
diff --git a/react/features/base/media/actionTypes.js b/react/features/base/media/actionTypes.js
index db54f1c610..625b87174f 100644
--- a/react/features/base/media/actionTypes.js
+++ b/react/features/base/media/actionTypes.js
@@ -1,3 +1,14 @@
+
+/**
+ * The type of (redux) action to adjust the availability of the local audio.
+ *
+ * {
+ *     type: SET_AUDIO_AVAILABLE,
+ *     muted: boolean
+ * }
+ */
+export const SET_AUDIO_AVAILABLE = 'SET_AUDIO_AVAILABLE';
+
 /**
  * The type of (redux) action to set the muted state of the local audio.
  *
@@ -9,14 +20,14 @@
 export const SET_AUDIO_MUTED = 'SET_AUDIO_MUTED';
 
 /**
- * The type of (redux) action to adjust the availability of the local audio.
+ * The type of (redux) action to enable/disable the audio mute icon.
  *
  * {
- *     type: SET_AUDIO_AVAILABLE,
- *     muted: boolean
+ *     type: SET_AUDIO_UNMUTE_PERMISSIONS,
+ *     blocked: boolean
  * }
  */
-export const SET_AUDIO_AVAILABLE = 'SET_AUDIO_AVAILABLE';
+export const SET_AUDIO_UNMUTE_PERMISSIONS = 'SET_AUDIO_UNMUTE_PERMISSIONS';
 
 /**
  * The type of (redux) action to set the facing mode of the local video camera
@@ -61,6 +72,16 @@ export const SET_VIDEO_MUTED = 'SET_VIDEO_MUTED';
  */
 export const STORE_VIDEO_TRANSFORM = 'STORE_VIDEO_TRANSFORM';
 
+/**
+ * The type of (redux) action to enable/disable the video mute icon.
+ *
+ * {
+ *     type: SET_VIDEO_UNMUTE_PERMISSIONS,
+ *     blocked: boolean
+ * }
+ */
+ export const SET_VIDEO_UNMUTE_PERMISSIONS = 'SET_VIDEO_UNMUTE_PERMISSIONS';
+
 /**
  * The type of (redux) action to toggle the local video camera facing mode. In
  * contrast to SET_CAMERA_FACING_MODE, allows the toggling to be optimally
diff --git a/react/features/base/media/actions.js b/react/features/base/media/actions.js
index 4195c361ee..b85e9707dd 100644
--- a/react/features/base/media/actions.js
+++ b/react/features/base/media/actions.js
@@ -9,9 +9,11 @@ import { isModerationNotificationDisplayed } from '../../notifications';
 import {
     SET_AUDIO_MUTED,
     SET_AUDIO_AVAILABLE,
+    SET_AUDIO_UNMUTE_PERMISSIONS,
     SET_CAMERA_FACING_MODE,
     SET_VIDEO_AVAILABLE,
     SET_VIDEO_MUTED,
+    SET_VIDEO_UNMUTE_PERMISSIONS,
     STORE_VIDEO_TRANSFORM,
     TOGGLE_CAMERA_FACING_MODE
 } from './actionTypes';
@@ -59,6 +61,19 @@ export function setAudioMuted(muted: boolean, ensureTrack: boolean = false) {
     };
 }
 
+/**
+ * Action to disable/enable the audio mute icon.
+ *
+ * @param {boolean} blocked - True if the audio mute icon needs to be disabled.
+ * @returns {Function}
+ */
+export function setAudioUnmutePermissions(blocked: boolean) {
+    return {
+        type: SET_AUDIO_UNMUTE_PERMISSIONS,
+        blocked
+    };
+}
+
 /**
  * Action to set the facing mode of the local camera.
  *
@@ -136,6 +151,19 @@ export function setVideoMuted(
     };
 }
 
+/**
+ * Action to disable/enable the video mute icon.
+ *
+ * @param {boolean} blocked - True if the video mute icon needs to be disabled.
+ * @returns {Function}
+ */
+export function setVideoUnmutePermissions(blocked: boolean) {
+    return {
+        type: SET_VIDEO_UNMUTE_PERMISSIONS,
+        blocked
+    };
+}
+
 /**
  * Creates an action to store the last video {@link Transform} applied to a
  * stream.
diff --git a/react/features/base/media/functions.js b/react/features/base/media/functions.js
index cce22cc218..97ab03c92d 100644
--- a/react/features/base/media/functions.js
+++ b/react/features/base/media/functions.js
@@ -88,6 +88,16 @@ export function getStartWithVideoMuted(stateful: Object | Function) {
     return Boolean(getPropertyValue(stateful, 'startWithVideoMuted', START_WITH_AUDIO_VIDEO_MUTED_SOURCES));
 }
 
+/**
+ * Determines whether video is currently muted.
+ *
+ * @param {Function|Object} stateful - The redux store, state, or {@code getState} function.
+ * @returns {boolean}
+ */
+export function isVideoMuted(stateful: Function | Object) {
+    return Boolean(toState(stateful)['features/base/media'].video.muted);
+}
+
 /**
  * Determines whether video is currently muted by the user authority.
  *
diff --git a/react/features/base/media/middleware.js b/react/features/base/media/middleware.js
index c0d8b9b37e..9733554237 100644
--- a/react/features/base/media/middleware.js
+++ b/react/features/base/media/middleware.js
@@ -8,6 +8,10 @@ import {
     sendAnalytics
 } from '../../analytics';
 import { APP_STATE_CHANGED } from '../../mobile/background';
+import {
+    NOTIFICATION_TIMEOUT_TYPE,
+    showWarningNotification
+} from '../../notifications';
 import { isForceMuted } from '../../participants-pane/functions';
 import { SET_AUDIO_ONLY, setAudioOnly } from '../audio-only';
 import { isRoomValid, SET_ROOM } from '../conference';
@@ -21,7 +25,12 @@ import {
     TRACK_ADDED
 } from '../tracks';
 
-import { SET_AUDIO_MUTED, SET_VIDEO_MUTED } from './actionTypes';
+import {
+    SET_AUDIO_MUTED,
+    SET_AUDIO_UNMUTE_PERMISSIONS,
+    SET_VIDEO_MUTED,
+    SET_VIDEO_UNMUTE_PERMISSIONS
+} from './actionTypes';
 import { setAudioMuted, setCameraFacingMode, setVideoMuted } from './actions';
 import {
     CAMERA_FACING_MODE,
@@ -74,6 +83,18 @@ MiddlewareRegistry.register(store => next => action => {
         break;
     }
 
+    case SET_AUDIO_UNMUTE_PERMISSIONS: {
+        const { blocked } = action;
+
+        if (blocked) {
+            store.dispatch(showWarningNotification({
+                descriptionKey: 'notify.audioUnmuteBlockedDescription',
+                titleKey: 'notify.audioUnmuteBlockedTitle'
+            }, NOTIFICATION_TIMEOUT_TYPE.LONG));
+        }
+        break;
+    }
+
     case SET_VIDEO_MUTED: {
         const state = store.getState();
         const participant = getLocalParticipant(state);
@@ -83,6 +104,18 @@ MiddlewareRegistry.register(store => next => action => {
         }
         break;
     }
+
+    case SET_VIDEO_UNMUTE_PERMISSIONS: {
+        const { blocked } = action;
+
+        if (blocked) {
+            store.dispatch(showWarningNotification({
+                descriptionKey: 'notify.videoUnmuteBlockedDescription',
+                titleKey: 'notify.videoUnmuteBlockedTitle'
+            }, NOTIFICATION_TIMEOUT_TYPE.LONG));
+        }
+        break;
+    }
     }
 
     return next(action);
diff --git a/react/features/base/media/reducer.js b/react/features/base/media/reducer.js
index 0813e59ce4..10db2e96b0 100644
--- a/react/features/base/media/reducer.js
+++ b/react/features/base/media/reducer.js
@@ -7,9 +7,11 @@ import { TRACK_REMOVED } from '../tracks/actionTypes';
 import {
     SET_AUDIO_AVAILABLE,
     SET_AUDIO_MUTED,
+    SET_AUDIO_UNMUTE_PERMISSIONS,
     SET_CAMERA_FACING_MODE,
     SET_VIDEO_AVAILABLE,
     SET_VIDEO_MUTED,
+    SET_VIDEO_UNMUTE_PERMISSIONS,
     STORE_VIDEO_TRANSFORM,
     TOGGLE_CAMERA_FACING_MODE
 } from './actionTypes';
@@ -33,6 +35,7 @@ import { CAMERA_FACING_MODE } from './constants';
  */
 export const _AUDIO_INITIAL_MEDIA_STATE = {
     available: true,
+    blocked: false,
     muted: false
 };
 
@@ -59,6 +62,12 @@ function _audio(state = _AUDIO_INITIAL_MEDIA_STATE, action) {
             muted: action.muted
         };
 
+    case SET_AUDIO_UNMUTE_PERMISSIONS:
+        return {
+            ...state,
+            blocked: action.blocked
+        };
+
     default:
         return state;
     }
@@ -83,6 +92,7 @@ function _audio(state = _AUDIO_INITIAL_MEDIA_STATE, action) {
  */
 export const _VIDEO_INITIAL_MEDIA_STATE = {
     available: true,
+    blocked: false,
     facingMode: CAMERA_FACING_MODE.USER,
     muted: 0,
 
@@ -126,6 +136,12 @@ function _video(state = _VIDEO_INITIAL_MEDIA_STATE, action) {
             muted: action.muted
         };
 
+    case SET_VIDEO_UNMUTE_PERMISSIONS:
+        return {
+            ...state,
+            blocked: action.blocked
+        };
+
     case STORE_VIDEO_TRANSFORM:
         return _storeVideoTransform(state, action);
 
diff --git a/react/features/talk-while-muted/middleware.js b/react/features/talk-while-muted/middleware.js
index 276535e7c7..ea70ba5f20 100644
--- a/react/features/talk-while-muted/middleware.js
+++ b/react/features/talk-while-muted/middleware.js
@@ -13,6 +13,7 @@ import {
     showNotification
 } from '../notifications';
 import { isForceMuted } from '../participants-pane/functions';
+import { isAudioMuteButtonDisabled } from '../toolbox/functions.any';
 
 import { setCurrentNotificationUid } from './actions';
 import { TALK_WHILE_MUTED_SOUND_ID } from './constants';
@@ -46,24 +47,27 @@ MiddlewareRegistry.register(store => next => action => {
             JitsiConferenceEvents.TALK_WHILE_MUTED, async () => {
                 const state = getState();
                 const local = getLocalParticipant(state);
-                const forceMuted = isForceMuted(local, MEDIA_TYPE.AUDIO, state);
-                const notification = await dispatch(showNotification({
-                    titleKey: 'toolbar.talkWhileMutedPopup',
-                    customActionNameKey: forceMuted ? 'notify.raiseHandAction' : 'notify.unmute',
-                    customActionHandler: () => dispatch(forceMuted ? raiseHand(true) : setAudioMuted(false))
-                }, NOTIFICATION_TIMEOUT_TYPE.LONG));
 
-                const { soundsTalkWhileMuted } = getState()['features/base/settings'];
+                // Display the talk while muted notification only when the audio button is not disabled.
+                if (!isAudioMuteButtonDisabled(state)) {
+                    const forceMuted = isForceMuted(local, MEDIA_TYPE.AUDIO, state);
+                    const notification = await dispatch(showNotification({
+                        titleKey: 'toolbar.talkWhileMutedPopup',
+                        customActionNameKey: forceMuted ? 'notify.raiseHandAction' : 'notify.unmute',
+                        customActionHandler: () => dispatch(forceMuted ? raiseHand(true) : setAudioMuted(false))
+                    }, NOTIFICATION_TIMEOUT_TYPE.LONG));
 
-                if (soundsTalkWhileMuted) {
-                    dispatch(playSound(TALK_WHILE_MUTED_SOUND_ID));
-                }
+                    const { soundsTalkWhileMuted } = getState()['features/base/settings'];
 
+                    if (soundsTalkWhileMuted) {
+                        dispatch(playSound(TALK_WHILE_MUTED_SOUND_ID));
+                    }
 
-                if (notification) {
-                    // we store the last start muted notification id that we showed,
-                    // so we can hide it when unmuted mic is detected
-                    dispatch(setCurrentNotificationUid(notification.uid));
+                    if (notification) {
+                        // we store the last start muted notification id that we showed,
+                        // so we can hide it when unmuted mic is detected
+                        dispatch(setCurrentNotificationUid(notification.uid));
+                    }
                 }
             });
         break;
diff --git a/react/features/toolbox/components/AudioMuteButton.js b/react/features/toolbox/components/AudioMuteButton.js
index 2a6d0aa8ef..41d982e55d 100644
--- a/react/features/toolbox/components/AudioMuteButton.js
+++ b/react/features/toolbox/components/AudioMuteButton.js
@@ -14,6 +14,7 @@ import { AbstractAudioMuteButton } from '../../base/toolbox/components';
 import type { AbstractButtonProps } from '../../base/toolbox/components';
 import { isLocalTrackMuted } from '../../base/tracks';
 import { muteLocal } from '../../video-menu/actions';
+import { isAudioMuteButtonDisabled } from '../functions';
 
 declare var APP: Object;
 
@@ -151,7 +152,7 @@ class AudioMuteButton extends AbstractAudioMuteButton<Props, *> {
  */
 function _mapStateToProps(state): Object {
     const _audioMuted = isLocalTrackMuted(state['features/base/tracks'], MEDIA_TYPE.AUDIO);
-    const _disabled = state['features/base/config'].startSilent;
+    const _disabled = state['features/base/config'].startSilent || isAudioMuteButtonDisabled(state);
     const enabledFlag = getFeatureFlag(state, AUDIO_MUTE_BUTTON_ENABLED, true);
 
     return {
diff --git a/react/features/toolbox/functions.any.js b/react/features/toolbox/functions.any.js
new file mode 100644
index 0000000000..4821db409e
--- /dev/null
+++ b/react/features/toolbox/functions.any.js
@@ -0,0 +1,13 @@
+// @flow
+
+/**
+ * Indicates if the audio mute button is disabled or not.
+ *
+ * @param {Object} state - The state from the Redux store.
+ * @returns {boolean}
+ */
+export function isAudioMuteButtonDisabled(state: Object) {
+    const { audio } = state['features/base/media'];
+
+    return !(audio?.available && !audio?.blocked);
+}
diff --git a/react/features/toolbox/functions.native.js b/react/features/toolbox/functions.native.js
index 47ccd5cea0..792d266c77 100644
--- a/react/features/toolbox/functions.native.js
+++ b/react/features/toolbox/functions.native.js
@@ -6,6 +6,8 @@ import { getParticipantCountWithFake } from '../base/participants';
 import { toState } from '../base/redux';
 import { isLocalVideoTrackDesktop } from '../base/tracks';
 
+export * from './functions.any';
+
 const WIDTH = {
     FIT_9_ICONS: 560,
     FIT_8_ICONS: 500,
@@ -78,5 +80,7 @@ export function isToolboxVisible(stateful: Object | Function) {
  * @returns {boolean}
  */
 export function isVideoMuteButtonDisabled(state: Object) {
-    return !hasAvailableDevices(state, 'videoInput') || isLocalVideoTrackDesktop(state);
+    const { video } = state['features/base/media'];
+
+    return !hasAvailableDevices(state, 'videoInput') || video?.blocked || isLocalVideoTrackDesktop(state);
 }
diff --git a/react/features/toolbox/functions.web.js b/react/features/toolbox/functions.web.js
index 2df9bcd5fd..ba231aed71 100644
--- a/react/features/toolbox/functions.web.js
+++ b/react/features/toolbox/functions.web.js
@@ -5,6 +5,8 @@ import { hasAvailableDevices } from '../base/devices';
 
 import { TOOLBAR_TIMEOUT } from './constants';
 
+export * from './functions.any';
+
 /**
  * Helper for getting the height of the toolbox.
  *
@@ -58,8 +60,9 @@ export function isToolboxVisible(state: Object) {
  * @returns {boolean}
  */
 export function isAudioSettingsButtonDisabled(state: Object) {
-    return (!hasAvailableDevices(state, 'audioInput')
-          && !hasAvailableDevices(state, 'audioOutput'))
+
+    return !(hasAvailableDevices(state, 'audioInput')
+          && hasAvailableDevices(state, 'audioOutput'))
           || state['features/base/config'].startSilent;
 }
 
@@ -80,7 +83,9 @@ export function isVideoSettingsButtonDisabled(state: Object) {
  * @returns {boolean}
  */
 export function isVideoMuteButtonDisabled(state: Object) {
-    return !hasAvailableDevices(state, 'videoInput');
+    const { video } = state['features/base/media'];
+
+    return !hasAvailableDevices(state, 'videoInput') || video?.blocked;
 }
 
 /**